منابع مشابه
Monitoring drug promiscuity over time
Drug promiscuity and polypharmacology are much discussed topics in pharmaceutical research. Experimentally, promiscuity can be studied by profiling of compounds on arrays of targets. Computationally, promiscuity rates can be estimated by mining of compound activity data. In this study, we have assessed drug promiscuity over time by systematically collecting activity records for approved drugs. ...
متن کاملMonitoring drug promiscuity over time [version 2; referees: 3 approved]
Drug promiscuity and polypharmacology are much discussed topics in pharmaceutical research. Experimentally, promiscuity can be studied by profiling of compounds on arrays of targets. Computationally, promiscuity rates can be estimated by mining of compound activity data. In this study, we have assessed drug promiscuity over time by systematically collecting activity records for approved drugs. ...
متن کاملPromiscuity progression of bioactive compounds over time
In the context of polypharmacology, compound promiscuity is rationalized as the ability of small molecules to specifically interact with multiple targets. To study promiscuity progression of bioactive compounds in detail, nearly 1 million compounds and more than 5.2 million activity records were analyzed. Compound sets were assembled by applying different data confidence criteria and selecting ...
متن کاملHealth Monitoring on Social Media over Time
Social media has become a major source for analyzing all aspects of daily life. Thanks to dedicated latent topic analysis methods such as the Ailment Topic Aspect Model (ATAM), public health can now be observed on Twitter. In this work, we are interested in monitoring people’s health over time. Recently, Temporal-LDA (TM–LDA) was proposed for efficiently modeling general-purpose topic transitio...
متن کاملBayesian perspective over time
Thomas Bayes, the founder of Bayesian vision, entered the University of Edinburgh in 1719 to study logic and theology. Returning in 1722, he worked with his father in a small church. He also was a mathematician and in 1740 he made a novel discovery which he never published, but his friend Richard Price found it in his notes after his death in 1761, reedited it and published it. But until L...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: F1000Research
سال: 2014
ISSN: 2046-1402
DOI: 10.12688/f1000research.5250.2